The Bredesen Protocol: A Functional Approach to Alzheimer’s and Cognitive Decline
An Evidence-Based Review by Dr. Eason at Revive Health
As a functional neurologist, I believe that treating neurodegenerative diseases, such as Alzheimer’s, requires a comprehensive and multifactorial approach. The Bredesen Protocol offers exactly that…
An innovative, personalized strategy for preventing or slowing cognitive decline associated with Alzheimer’s disease.
This protocol has gained attention for its holistic focus on the multiple factors that contribute to cognitive health. Yet, like any emerging treatment, it has its critics. And, as is often the case with complex chronic illnesses, the questions surrounding its efficacy may never have a simple answer. But that doesn’t mean we shouldn’t explore it thoroughly. Alzheimer’s disease, which affects millions worldwide, requires all of us to search for innovative solutions.
In this review, we’ll take a closer look at what the Bredesen Protocol entails, the evidence supporting it, the criticisms it faces, and how it fits into a holistic approach to cognitive health.
What Is The Bredesen Protocol?
The Bredesen Protocol is a multifaceted approach to Alzheimer’s prevention and reversal. It centers on the idea that cognitive decline, particularly Alzheimer’s disease, is not caused by a single factor but rather by a combination of multiple environmental, lifestyle, and genetic factors.
Developed by Dr. Dale Bredesen, a neurologist with over 30 years of experience studying Alzheimer’s disease, the protocol involves seven core strategies aimed at reversing cognitive decline. These strategies are rooted in the functional medicine model, emphasizing root cause resolution rather than just symptom management.
They include:
Nutrition
Exercise
Sleep
Stress management
Brain stimulation
Detoxification
Supplementation
As a functional neurologist at Revive Health, I integrate these principles into a broader framework of personalized care, treating the whole person and addressing the underlying causes of neurological decline.
These strategies align with my practice’s focus on precision medicine—personalized interventions that align with each individual’s unique health needs.
History of the Bredesen Protocol
Dr. Bredesen introduced his protocol in a 2014 paper titled Reversal of Cognitive Decline: A Novel Therapeutic Approach. His work was groundbreaking in suggesting that Alzheimer’s could not only be slowed but, in some cases, reversed. The protocol has since attracted attention due to small studies showing promising results for cognitive improvement in individuals with Alzheimer’s and cognitive decline.
Dr. Bredesen's framework addresses the complex nature of Alzheimer’s by recognizing the interplay of various genetic and environmental factors that lead to cognitive dysfunction. This makes it different from traditional medical approaches, which typically focus on symptomatic treatments.
The Key Strategies of the Bredesen Protocol
The Bredesen Protocol is not just about one thing—it’s a holistic, multifactorial approach. Here’s a breakdown of the core strategies involved:
Nutrition: The protocol recommends an anti-inflammatory, low-carb, plant-rich diet designed to optimize fat-burning, improve brain function, and reduce inflammation. Key strategies include intermittent fasting and exercise, both shown to support brain health.
Exercise: Regular physical activity, including aerobic and resistance training, is essential for stimulating brain growth, improving cognitive function, and reducing cognitive decline.
Sleep: Quality sleep is crucial for cognitive health. Sleep apnea and other sleep disorders are addressed, as poor oxygen intake at night is linked to brain deterioration.
Stress: Chronic stress increases cortisol levels, which can be detrimental to brain health. Stress-reducing practices, such as mindfulness, yoga, and therapy, are part of the protocol to reduce inflammation and support brain function.
Brain Stimulation: Cognitive exercises, such as memory training, and engaging in new learning activities, help improve brain function and memory retention.
Detoxification: Reducing exposure to toxins (such as heavy metals, mold, and certain chemicals) is part of the process of protecting brain health.
Supplementation: Supplements that support brain health, like vitamins D and B12, omega-3 fatty acids, and antioxidants, are recommended to address any imbalances and support cognitive health.
Criticisms of the Bredesen Protocol
Despite its success and popularity, the Bredesen Protocol has faced some criticism, particularly regarding the following areas:
Lack of High-Quality Evidence: Critics point out that most of the research supporting the protocol is limited to observational studies and case reports. While these can provide valuable insights, they are not as rigorous as randomized, placebo-controlled trials, which are often considered the "gold standard" in research.
Cost: Some individuals find the protocol’s extensive testing, consultations, and supplements expensive, with limited insurance coverage. However, the potential for improving quality of life and reducing long-term healthcare costs can outweigh the initial investment for many.
Supplements: The use of supplements is a controversial aspect. While many supplements show benefits for cognitive health (such as reducing inflammation), the effectiveness of some Bredesen-recommended supplements for reversing Alzheimer’s is still up for debate.
Benefits of the Bredesen Protocol
Despite criticisms, the Bredesen Protocol offers several significant benefits:
Reduced Risk of Cognitive Decline: Studies have shown that the protocol can reduce beta-amyloid plaques and improve cognitive function. These plaques are a hallmark of Alzheimer’s disease.
Improved Memory: Personalized diet and lifestyle changes, combined with cognitive stimulation, may lead to improvements in memory and overall cognitive function.
Decreased Inflammation: Anti-inflammatory diets, supplements, and detox strategies reduce inflammation in the brain, which is a major contributor to Alzheimer’s progression.
Increased Brain Function and Protection: Strategies like sleep optimization, brain stimulation, and nutrient supplementation help protect brain cells and even encourage neurogenesis (the growth of new brain cells).
Is the Bredesen Protocol For You?
If you're looking for a holistic, multifactorial approach to protecting brain health and slowing cognitive decline, the Bredesen Protocol may be an option worth considering. It is especially valuable for individuals at risk of Alzheimer’s or those experiencing early signs of cognitive decline.
At Revive Health, we take a comprehensive, personalized approach to brain health.
As a functional neurologist, I believe that combining conventional and integrative approaches provides the best chance of success. Whether through lifestyle changes, targeted supplementation, or cognitive interventions, our goal is to support your brain function and optimize your overall health.
Dr. Eason and the team at Revive Health are here to help!
For those struggling with cognitive decline or interested in preventive strategies, Dr. Eason and the team at Revive Health are here to help. We offer tailored functional medicine consultations to explore the Bredesen Protocol and other treatment options that fit your specific needs.
If you’re ready to take control of your brain health, don’t hesitate to book a consultation with us today.
